The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection
TL;DR 摘要总结
DNA甲基化检测在分流非16/18型高危HPV感染女性中优于液基细胞学检查。该方法能有效识别宫颈病变高风险患者，显著降低不必要的阴道镜检查转诊率，尤其与HPV33/35基因分型联合应用时效果更佳，为宫颈癌筛查提供更精准的风险分层工具。
摘要 · Abstract
METHODS: This study compared the triage performance of liquid-based cytology (LBC) testing, hrHPV genotyping, and PAX1/JAM3 gene methylation (CISCER) testing. The absolute risks of cervical intraepithelial neoplasia grade 2 or worse (CIN2+), grade 3 or worse (CIN3+), and colposcopy referral rates were calculated
RESULTS: The CISCER test showed a CIN3+ risk of 39.1% for positive and 0.9% for negative results. In comparison, LBC?��?ASCUS and HPV33/35 genotyping had CIN3+ risks of 9.8% and 19.3%, respectively, for positive result. The colposcopy referral rates were 17.4% for CISCER+, 61.9% for LBC?��?ASCUS, and 8.9% for HPV33/35+ genotyping. The CIN3+ risks were 40.0% and 50.0% when CISCER+ was combined with LBC?��?ASCUS and HPV33/35+, respectively. The CIN3+ risks were 0.0% and 1.0% when CISCER- was combined with LBC with no intraepithelial lesions or malignancy (NILM) and non-HPV33/35, respectively. Our analysis of CIN2+ patients yielded similar results
CONCLUSIONS: DNA methylation testing outperformed LBC in triaging women with non-16/18 hrHPV infections, significantly reducing unnecessary colposcopy referrals, particularly when combined with HPV33/35 genotyping.
发表单位
Peking Union Medical College Hospital
引用格式
Su, H. et al. The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection. Br J Cancer 1–8 (2025) doi:10.1038/s41416-025-03005-5.
文献海报 · Poster
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